Starting 19 October 2015, NHS Trusts will not be using agency staff from off-Framework recruitment agencies.
The reason for this is that off-Framework agencies charge more than approved agencies and have fewer compliance/checks in place.
How does this affect you? If you already work with an approved agency, you have no reasons to worry.
On another hand, if you currently work with an off-Framework agency, you should move to a Framework agency as soon as possible.